solid lipid nanoparticles of ciprofloxacin hydrochloride with enhanced antibacterial activity
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چکیده
منابع مشابه
Solid Lipid Nanoparticles of a Water Soluble Drug, Ciprofloxacin Hydrochloride
The aim of this study was to understand and investigate the relationship between experimental factors and their responses in the preparation of ciprofloxacin hydrochloride based solid lipid nanoparticles. A quadratic relationship was studied by developing central composite rotatable design. Amount of lipid and drug, stirring speed and stirring time were selected as experimental factors while pa...
متن کاملCorrigendum to “Ciprofloxacin Controlled-Solid Lipid Nanoparticles: Characterization, In Vitro Release, and Antibacterial Activity Assessment”
[This corrects the article DOI: 10.1155/2017/2120734.].
متن کاملCiprofloxacin Controlled-Solid Lipid Nanoparticles: Characterization, In Vitro Release, and Antibacterial Activity Assessment
The objective of this research was to formulate ciprofloxacin (CIP) in solid lipid nanoparticles (SLNs) in an attempt to develop a controlled drug delivery system. An ultrasonic melt-emulsification method was used for preparing CIP-loaded SLNs. Key findings included that SLNs were successfully produced with average particle sizes ranging from 165 to 320 nm and polydispersity index in the range ...
متن کاملVorinostat Pretreatment Enhanced Ciprofloxacin-Induced Antibacterial Activity
The mechanism of ciprofloxacin action involves interference with transcription and replication of bacterial DNA, which results in elevated oxidative stress, and bacterial cell death. Vorinostat was shown to induce oxidative DNA damage. In the current work, the possibility for interactive effect of vorinotat on ciprofloxacin-induced cytotoxicity against a number of reference bacteria was investi...
متن کاملDevelopment and Evaluation of Solid Lipid Nanoparticles of Raloxifene Hydrochloride for Enhanced Bioavailability
Raloxifene hydrochloride (RL-HCL) is an orally selective estrogen receptor modulator (SERM) with poor bioavailability of nearly 2% due to its poor aqueous solubility and extensive first pass metabolism. In order to improve the oral bioavailability of raloxifene, raloxifene loaded solid lipid nanoparticles (SLN) have been developed using Compritol 888 ATO as lipid carrier and Pluronic F68 as sur...
متن کاملFormulation & Evaluation of Gemcitabine Hydrochloride Loaded Solid Lipid Nanoparticles
INTRODUCTION Gemcitabine hydrochloride is an antimetabolite (pyrimidine analog) with poor oral bioavailability (9%) due to the first pass metabolism. GEM is a water soluble drug (log p = -1.4) with a short half-life of 42 to 94 minutes (short infusions) and 245 to 638 minutes (long infusions) respectively. Extensive first pass metabolism, low bioavailability, high dosing frequency and less half...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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